Discontinuation syndrome

Discontinuation syndrome is the set of temporary symptoms that can appear when an antidepressant is stopped too quickly. It isn't addiction, and it's usually prevented by tapering the dose gradually with a prescriber.

Definition from Shrinktionary, reviewed by Shariq Refai, MD, MBA, FAPA (last reviewed 2026-06-26). Shrinktionary is the network's language layer and carries the canonical short definition; this page adds the research-context detail below. Full definition on Shrinktionary →

After the body adjusts to an antidepressant, stopping it suddenly can cause temporary symptoms. These can include dizziness, flu-like feelings, sleep trouble, irritability, and brief electric-shock sensations. The symptoms are usually short-lived. They're more likely with medications that leave the body quickly, such as paroxetine and venlafaxine.

SSRIs and SNRIs are first-line medications for anxiety, so discontinuation syndrome is a practical issue for many patients. It is a key reason clinicians lower these medications slowly, with a taper, instead of stopping all at once. It can also be mistaken for a return of anxiety, which can confuse decisions about treatment.

A person stops an SNRI abruptly and feels dizzy and unwell for a week. This is discontinuation syndrome, not necessarily a sign that their anxiety has come back.

Discontinuation syndrome isn't the same as addiction in the way that word is usually meant. It's a predictable physical adjustment. It is also a reason not to stop an antidepressant on your own. A clinician can plan a taper that lowers the risk.